GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
Summary: Molecular mechanisms mediating cardiac hypertrophy by glucose metabolism are incompletely understood.Hexosamine biosynthesis Waterproof Overtrousers pathway (HBP), an accessory pathway of glycolysis, is known to be involved in the attachment of O-linked N-acetylglucosamine motif (O-GlcNAcylation) to proteins, a post-translational modificat